Auris Nasus Larynx
Volume 39, Issue 1 , Pages 9-17 , February 2012

A novel concept of Mikulicz's disease as IgG4-related disease

  • Tetsuo Himi

      Affiliations

    • Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    • Corresponding Author InformationCorresponding author at: South 1, West 16, Sapporo 060-8543, Japan. Tel.: +81 11 611 2111x3491; fax: +81 11 615 5405.
    • ,
  • Kenichi Takano

      Affiliations

    • Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    • ,
  • Motohisa Yamamoto

      Affiliations

    • First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    • ,
  • Yasuyoshi Naishiro

      Affiliations

    • First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    • ,
  • Hiroki Takahashi

      Affiliations

    • First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

Received 10 December 2010 ,Accepted 28 January 2011.

References 

  1. Aalberse RC, Stapel SO, Schuurman J, Rispens T. Immunoglobulin G4: an odd antibody. Clin Exp Allergy. 2009;39:469–477
  2. Lock RJ, Unsworth DJ. Immunoglobulins and immunoglobulin subclass in the elderly. Ann Clin Biochem. 2003;40:143–148
  3. Yamamoto M, Takahashi H, Sugai S, Imai K. Clinical and pathological characteristics of Mikulicz's disease (IgG4-related plasmacytic exocrinopathy). Autoimmun Rev. 2005;4:195–200
  4. Kitagawa S, Zen Y, Harada K, Sasaki M, Sato Y, Minato H, et al. Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Küttner's tumor). Am J Surg Pathol. 2005;29:783–791
  5. Takano K, Yamamoto M, Takahashi H, Shinomura Y, Imai K, Himi T. Clinicopathological similarities between Mikulicz disease and Küttner tumor. Am J Otolaryngol. 2010;31:429–434
  6. Morgan WS, Castleman B. A clinicopathologic study of “Mikulicz's disease”. Am J Pathol. 1953;29:471–503
  7. Kuczkowski J, Stankiewicz C, Kopacz A, Narozny W, Mikaszewski B, Drucis K. Jan Mikulicz-Radecki (1850–1905): pioneer of endoscopy and surgery of the sinuses, throat, and digestive tract. World J Surg. 2004;28:1063–1067
  8. Gorecki P, Gorecki W. Jan Mikulicz-Radecki (1850–1905) – the creator of modern European surgery. Dig Surg. 2002;19:313–318
  9. Mikulicz J. Über eine eigenartige symmetrishe Erkrankung der Thranen und Mundspeicheldrüsen. Stuttgart: Beitr Chir Fortsch Gewidmet Theodor Billroth; 1892. p. 610–30.
  10. Schaffer AJ, Jacobsen AW. Mikulicz's syndrome: a report of ten cases. Am J Dis Child. 1927;34:327–346
  11. Sjögren H. Zur Kenntnis der Keratoconjunctivitis Sicca (Keratitis filiformis bei Hypofunktion der Tranendrusen). Acta Ophthalmol 1933;(Suppl. II):1–151.
  12. Konno A, Ito E, Okamoto Y. The clinical, histopathological and electronmicroscopical study of chronic parotitis, Sjögren syndrome and Mikulicz disease. J Jpn Saliv Gl 1984;25:1–33 [in Japanese].
  13. Konno A, Ito E. Mikulicz disease. Jibi Inkoka Tokeibu Geka (Otolaryngology-Head and Neck Surgery [Tokyo]) 1989;61:426–7 [in Japanese].
  14. Zandbelt MM, van den Hoogen FH, de Wilde PC, van den Berg PJ, Schneider HG, van de Putte LB. Reversibility of histological and immunohistological abnormalities in sublabial salivary gland biopsy specimens following treatment with corticosteroids in Sjögren's syndrome. Ann Rheum Dis. 2001;60:511–513
  15. Tsubota K, Fujita H, Tsuzaka K, Takeuchi T. Mikulicz's disease and Sjögren's syndrome. Invest Ophthalmol Vis Sci. 2000;41:1666–1673
  16. Tsubota K, Fujita H, Tadano K, Onoda N, Tsuzaka K, Takeuchi T. Abnormal expression and function of Fas ligand of lacrimal glands and peripheral blood in Sjögren's syndrome patients with enlarged exocrine glands. Clin Exp Immunol. 2002;129:177–182
  17. Küttner H. Ueber entzündliche tumoren der submaxillar-speicheldrüse. Beitr Klin Chir. 1896;15:815–834
  18. Ellis GL, Auclair PL. Tumor-like conditions. In:  Ellis GL,  Auclair PL editor. Tumors of the salivary glands. Washington, DC: Armed Forces Institute of Pathology; 1996;p. 412–419
  19. Isacsson G, Ahlner B, Lundquist PG. Chronic sialadenitis of the submandibular gland: a retrospective study of 108 cases. Arch Otorhinolaryngol. 1981;232:91–100
  20. Chan JK. Küttner tumor (chronic sclerosing sialadenitis) of the submandibular gland: an underrecognized entity. Adv Anat Pathol. 1998;5:239–251
  21. Harrison JD, Epivatianos A, Bhatia SN. Role of microliths in the aetiology of chronic submandibular sialadenitis: a clinicopathological investigation of 154 cases. Histopathology. 1997;31:237–251
  22. Ikeda M, Ikui A, Tanaka M, Omori H, Tomita H. Immunohistopathological investigation on unspecific chronic sclerosing sialadenitis of the submandibular gland (Küttner tumor). Auris Nasus Larynx. 1994;21:103–110
  23. Rasanen O, Jokinen K, Dammert K. Sclerosing inflammation of the submandibular salivary gland (Küttner tumour): a progressive plasmacellular ductitis. Acta Otolaryngol. 1972;74:297–301
  24. Tiemann M, Teymoortash A, Schrader C, Werner JA, Parwaresch R, Seifert G, et al. Chronic sclerosing sialadenitis of the submandibular gland is mainly due to a T lymphocyte immune reaction. Mod Pathol. 2002;15:845–852
  25. Nieminen U, Koivisto T, Kahri A, Färkkilä M. Sjögren's syndrome with chronic pancreatitis, sclerosing cholangitis, and pulmonary infiltrations. Am J Gastroenterol. 1997;92:139–142
  26. Sekine S, Nagata M, Watanabe T. Chronic sclerosing sialadenitis of the submandibular gland associated with idiopathic retroperitoneal fibrosis. Pathol Int. 1999;49:663–667
  27. Tsuneyama K, Saito K, Ruebner BH, Konishi I, Nakanuma Y, Gershwin ME. Immunological similarities between primary sclerosing cholangitis and chronic sclerosing sialadenitis: report of the overlapping of these two autoimmune diseases. Dig Dis Sci. 2000;45:366–372
  28. Dooreck BS, Katz P, Barkin JS. Autoimmune pancreatitis in the spectrum of autoimmune exocrinopathy associated with sialoadenitis and anosmia. Pancreas. 2004;28:105–107
  29. Zen Y, Harada K, Sasaki M, Sato Y, Tsuneyama K, Haratake J, et al. IgG4-related sclerosing cholangitis with and without hepatic inflammatory pseudotumor, and sclerosing pancreatitis-associated sclerosing cholangitis: do they belong to a spectrum of sclerosing pancreatitis?. Am J Surg Pathol. 2004;28:1193–1203
  30. Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med. 2001;344:732–738
  31. Fox PC, Datiles M, Atkinson JC, Macynski AA, Scott J, Fletcher D, et al. Prednisolene and piroxicam for treatment of primary Sjögren's syndrome. Clin Exp Rheumatol. 1993;11:149–156
  32. Moutsopoulos HM. Sjögren syndrome. In:  Braunwald E,  Fauci AS,  Kasper DL,  Hauser SL,  Longo DL,  Jameson JL, et al. editor. Harrison's principles of internal medicine. 15th ed.. New York: McGraw-Hill; 2001;p. 1947–1949
  33. Naguwa S, Gershwin ME. Sjögren syndrome. In:  Goldman L,  Ausiello D editor. Cecil textbook of internal medicine. 22nd ed.. Philadelphia: Saunders; 2004;p. 1677–1680
  34. Shakib F, Stanworth DR. Human IgG subclasses in health and disease. Ric Clin Lab. 1980;10:561–580
  35. French M. Serum IgG subclasses in normal adults. Monogr Allergy. 1986;19:100–107
  36. Murphy SL, Li H, Mingozzi F, Sabatino DE, Hui DJ, Edmonson SA, et al. Diverse IgG subclass responses to adeno-associated virus infection and vector administration. J Med Virol. 2009;81:65–74
  37. Aalberse RC, Schuurman J. IgG4 breaking the rules. Immunology. 2002;105:9–19
  38. Yamamoto M, Harada S, Ohara M, Suzuki C, Naishiro Y, Yamamoto H, et al. Clinical and pathological differences between Mikulicz's disease and Sjögren's syndrome. Rheumatology (Oxford). 2005;44:227–234
  39. Parlowsky T, Welzel J, Amagai M, Zillikens D, Wygold T. Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns. J Am Acad Dermatol. 2003;48:623–625
  40. Warren SJ, Arteaga LA, Rivitti EA, Aoki V, Hans-Filho G, Qaqish BF, et al. The role of subclass switching in the pathogenesis of endemic pemphigus foliaceus. J Invest Dermatol. 2003;120:104–108
  41. Yamamoto M, Takahashi H, Suzuki C, Tabeya T, Ohara M, Naishiro Y, et al. Analysis of serum IgG subclasses in Churg-Strauss syndrome − the meaning of elevated serum levels of IgG4. Intern Med. 2010;49:1365–1370
  42. Oliveira DB. Membranous nephropathy: an IgG4-mediated disease. Lancet. 1998;351:670–671
  43. Ayatollahi M, Joubeh S, Mortazavi H, Jefferis R, Ghaderi A. IgG4 as the predominant autoantibody in sera from patients with active state of pemphigus vulgaris. J Eur Acad Dermatol Venereol. 2004;18:241–242
  44. Takano K, Yamamoto M, Kondo A, Himi T. A case of reversible hyposmia associated with Mikulicz's disease. Otolaryngol Head Neck Surg. 2009;141:430–431
  45. Tanaka S, Kobayashi T, Nakanishi K, Okubo M, Murase T, Hashimoto M, et al. Corticosteroid-responsive diabetes mellitus associated with autoimmune pancreatitis. Lancet. 2000;356:910–911
  46. Hamano H, Kawa S, Ochi Y, Unno H, Shiba N, Wajiki M, et al. Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis. Lancet. 2002;359:1403–1404
  47. Yamamoto M, Takahashi H, Ohara M, Suzuki C, Naishiro Y, Yamamoto H, et al. Case of Mikulicz's disease (IgG4-related plasmacytic disease) complicated by autoimmune hypophysitis. Scand J Rheumatol. 2006;35:410–411
  48. Kamisawa T, Nakajima H, Egawa N, Funata N, Tsuruta K, Okamoto A. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol. 2003;38:982–984
  49. Fukui T, Okazaki K, Yoshizawa H, Ohashi S, Tamaki H, Kawasaki K, et al. A case of autoimmune pancreatitis associated with sclerosing cholangitis, retroperitoneal fibrosis and Sjögren syndrome. Pancreatology. 2005;5:86–91
  50. Duvic C, Desrame J, Lévêque C, Nedelec G. Retroperitoneal fibrosis, sclerosing pancreatitis and bronchiolitis obliterans with organizing pneumonia. Nephrol Dial Transplant. 2004;19:2397–2399
  51. Saeki T, Saito A, Hiura T, Yamazaki H, Emura I, Ueno M, et al. Lymphoplasmacytic infiltration of multiple organs with immunoreactivity for IgG4: IgG4-related systemic disease. Intern Med. 2006;45:163–167
  52. Isacsson G, Ahlner B, Lundquist PG. Chronic sialadenitis of the submandibular gland: a retrospective study of 108 case. Arch Otorhinolaryngol. 1981;232:91–100
  53. Rasanen O, Jokinen K, Dammert K. Sclerosing inflammation of the submandibular salivary gland (Kuttner tumour): a progressive plasmacellular ductitis. Acta Otolaryngol. 1972;74:297–301
  54. Yamamoto M, Harada S, Ohara M, Suzuki C, Naishiro Y, Yamamoto H, et al. Beneficial effects of steroid therapy for Mikulicz's disease. Rheumatology (Oxford). 2005;44:1322–1323
  55. Yamamoto M, Takahashi H, Ohara M, Suzuki C, Naishiro Y, Yamamoto H, et al. A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease. Mod Rheumatol. 2006;16:335–340
  56. Masaki Y, Dong L, Kurose N, Kitagawa K, Morikawa Y, Yamamoto M, et al. Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis. 2009;68:1310–1315
  57. Kamisawa T, Okamoto A. IgG4-related sclerosing disease. World J Gastroenterol. 2008;14:3948–3955
  58. Cheuk W, Chan JK. IgG4-related sclerosing disease: a critical appraisal of an evolving clinicopathologic entity. Adv Anat Pathol. 2010;17:303–332
  59. Richter JT, Strange RG, Fisher SI, Miller DV, Delvecchio DM. Extranodal Rosai-Dorfman disease presenting as a cardiac mass in an adult: report of a unique case and lack of relationship to IgG4-related sclerosing lesions. Hum Pathol. 2010;41:297–301
  60. Miyake K, Moriyama M, Aizawa K, Nagano S, Inoue Y, Sadanaga A, et al. Peripheral CD4+ T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion. Mod Rheumatol. 2008;18:86–90
  61. Kudo-Tanaka E, Nakatsuka S, Hirano T, Kawai M, Katada Y, Matsushita M, et al. A case of Mikulicz's disease with Th2-biased cytokine profile: possible feature discriminable from Sjögren's syndrome. Mod Rheumatol. 2009;19:691–695
  62. Zen Y, Fujii T, Harada K, Kawano M, Yamada K, Takahira M, et al. Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitis. Hepatology. 2007;45:1538–1546
  63. Jeannin P, Lecoanet S, Delneste Y, Gauchat JF, Bonnefoy JY. IgE versus IgG4 production can be differentially regulated by IL-10. J Immunol. 1998;160:3555–3561

PII: S0385-8146(11)00126-X

doi: 10.1016/j.anl.2011.01.023

Auris Nasus Larynx
Volume 39, Issue 1 , Pages 9-17 , February 2012

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