Abstract
Objective
We aim to explore the clinical features and influencing factors of curative effect
in children harboring acute laryngitis with laryngeal obstruction.
Methods
There involved 237 children with acute laryngitis and 80 healthy children who required
physical examination in our hospital between January and September in 2021. The healthy
children who required physical examination were allocated into the healthy/control
group. The clinical data and laboratory indexes of each group were compared. We also
analyzed the risk factors for curative effect of acute laryngitis with laryngeal obstruction
among children using univariate/multivariate logistic regression.
Results
The incidence of barking cough, sore throat, dryness, pruritus, dyspnea, diffuse congestion
and swelling of laryngeal mucosa and vocal cord congestion or covered with vascular
striation in degree III laryngeal obstruction group were significantly higher than
other study groups, with degree II laryngeal obstruction group higher than degree
I group, and degree I group higher than no laryngeal obstruction group (P<0.05). Moreover,
the levels of CRP, TNF-α, IL-6, IL-8 and WBC in degree III laryngeal obstruction group
were higher than other three study groups, with degree II higher than degree I laryngeal
obstruction group and no obstruction group, and degree I higher than no laryngeal
obstruction group (P<0.05). Multivariate logistic regression analysis showed that
CRP, TNF-α, IL-6 and IL-8 were the risk factors affecting the curative effect of acute
laryngitis with laryngeal obstruction in children, and the differences were statistically
significant (P<0.05).
Conclusion
The study revealed the incidence of barking cough, sore throat, dryness, pruritus,
dyspnea, diffuse congestion and swelling of laryngeal mucosa vocal cord congestion
or covered with vascular striation is highly associated with the severity of acute
laryngitis with laryngeal obstruction in children. Additionally, higher levels of
CRP, TNF-α, IL-6, IL-8 and WBC indicated serious condition of the disease among children.
Hence the risk factors responsible for the efficacy of acute laryngitis in children
are CRP, TNF-α, IL-6 and IL-8.
Keywords
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Article info
Publication history
Published online: July 02, 2022
Accepted:
June 17,
2022
Received:
February 6,
2022
Identification
Copyright
© 2022 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc. Published by Elsevier B.V. All rights reserved.