Abstract
Objective
To evaluate the effects of DX and HA on hearing preservation and tissue response with
cochlear implantation in a cat mode.
Methods
11 cats were bilaterally implanted with Nurotron electrode. According to the different
treatment, 22 ears were subdivided into four following groups: Electrode (E) only,
Electrode +HA (E+H), Electrode + DX (E+DX), and Electrode +HA +DX (E+H+DX). Auditory
brainstem responses (ABR) thresholds were recorded before and 3 months after surgery.
After 3 months of cochlear implantation histopathological assessment of all cochleae
were performed .
Results
At low frequencies, the mean ABR thresholds shift in animals treated with E+H+DX demonstrated
a statistically significant difference. The proportion of cochleae showing fibrous
tissue and new bone formation was 50% in E+H+DX group, 66.7% in E+DX group, 83.3%
in E+H group and 100% in E group.
Conclusion
United HA and DX local delivery could provide better protection against hearing loss
at low-frequency threshold and could more effectively reduce the trauma related to
electrode insertion and the fibrous tissue formation around the electrode.
Keywords
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Article info
Publication history
Published online: July 22, 2022
Accepted:
July 8,
2022
Received:
April 19,
2022
Identification
Copyright
© 2022 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc. Published by Elsevier B.V. All rights reserved.