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Research Article| Volume 50, ISSUE 2, P228-234, April 2023

Evaluation of the hearing preservation and tissue response of dexamethasone and hyaluronic acid delivery during cochlear implantation on cats in a three-month period study

  • Author Footnotes
    1 Nirmal Thapa and Yu Zheng contributed equally to this work
    Nirmal Thapa
    Footnotes
    1 Nirmal Thapa and Yu Zheng contributed equally to this work
    Affiliations
    ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China

    NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 20031, China

    Shanghai clinical medical center of hearing medicine, Shanghai 200031, China

    Otology and Neurotology of Miller School of Medicine, Miami University, 9375 SW 77th Avenue, #1019, 33156 Miami, USA
    Search for articles by this author
  • Author Footnotes
    1 Nirmal Thapa and Yu Zheng contributed equally to this work
    Yu Zheng
    Footnotes
    1 Nirmal Thapa and Yu Zheng contributed equally to this work
    Affiliations
    ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China

    NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 20031, China

    Shanghai clinical medical center of hearing medicine, Shanghai 200031, China
    Search for articles by this author
  • Na Gao
    Correspondence
    Corresponding author.
    Affiliations
    ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China

    NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 20031, China

    Shanghai clinical medical center of hearing medicine, Shanghai 200031, China
    Search for articles by this author
  • Fanglu Chi
    Affiliations
    ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China

    NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 20031, China

    Shanghai clinical medical center of hearing medicine, Shanghai 200031, China
    Search for articles by this author
  • Author Footnotes
    1 Nirmal Thapa and Yu Zheng contributed equally to this work

      Abstract

      Objective

      To evaluate the effects of DX and HA on hearing preservation and tissue response with cochlear implantation in a cat mode.

      Methods

      11 cats were bilaterally implanted with Nurotron electrode. According to the different treatment, 22 ears were subdivided into four following groups: Electrode (E) only, Electrode +HA (E+H), Electrode + DX (E+DX), and Electrode +HA +DX (E+H+DX). Auditory brainstem responses (ABR) thresholds were recorded before and 3 months after surgery. After 3 months of cochlear implantation histopathological assessment of all cochleae were performed .

      Results

      At low frequencies, the mean ABR thresholds shift in animals treated with E+H+DX demonstrated a statistically significant difference. The proportion of cochleae showing fibrous tissue and new bone formation was 50% in E+H+DX group, 66.7% in E+DX group, 83.3% in E+H group and 100% in E group.

      Conclusion

      United HA and DX local delivery could provide better protection against hearing loss at low-frequency threshold and could more effectively reduce the trauma related to electrode insertion and the fibrous tissue formation around the electrode.

      Keywords

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