Abstract
Objective
This report describes a case of a 62-year-old male with giant cell carcinoma of the
larynx that presented as a neck mass and hoarseness.
Methods
Case report, review of the world literature, and an immunohistochemical examination.
Results
Extended total laryngectomy and bilateral functional neck dissection were performed.
Microscopical examination showed that the tumor was composed of solid masses of anaplastic
small cells with hyperchromatic nuclei. There were multinucleated giant cells with
huge nuclei, prominent nucleoli, and clear or eosinophylic cytoplasm. The diagnosis
of giant cell carcinoma of the larynx was made. An immunohistochemical staining was
applied to the case and tumor showed immunoreactivity with cytokeratin 8/18, cytokeratin
18, cytokeratin 19, vimentin, epithelial membrane antigen, S-100, cytokeratin 7 and
did not show immunoreactivity with cytokeratin 10, cytokeratin 20, and carcinoembryogenic
antigen.
Conclusion
Giant cell carcinoma of the larynx is an extremely rare tumor the origin of which
is not clearly understood. It is believed to be the counterpart of giant cell carcinoma
of the lung in larynx. It is the sixth case reported in English literature and also
the first case that is examined immunohistochemically. In conclusion, giant cell carcinoma
of the larynx is confirmed to be a specific entity of simple epithelial origin and
it is the counterpart of giant cell carcinoma of the lung.
Keywords
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Article info
Publication history
Accepted:
January 19,
2007
Received:
April 4,
2006
Identification
Copyright
© 2007 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
