Abstract
Objective
The aim of this study was to investigate how isotonic sea water solution (Physiomer)
affects the structure of porcine nasal mucosa when it is applied simultaneously with
vasoconstrictors (xylometazoline) for a prolonged period of time.
Methods
Twenty pigs of the PMR-Landraze breed formed the study group. A solution of xylometazoline
0, 1% (Otrivin spray, Novartis) was sprayed every 8 h in both nasal cavities of the pigs, with two applications into each nostril for
28 days. Between the applications (4 h later), the right nasal cavity was washed with sterile isotonic sea water (Physiomer
Normal, Geomar). Biopsies were taken under endoscopic guidance from the nasal mucosa
of each nasal cavity separately at specific times. Five histological parameters were
microscopically examined for each biopsy section: (1) inflammation, (2) fibrosis,
(3) metaplasia of the epithelium, (4) reactive atypia of the epithelium and (5) necrosis.
Results
Statistically significant differences regarding grade of inflammation on days 7 (p = 0.0009), 12 (p = 0.01), 20 (p = 0.02) and 28 (p = 0.0005), regarding grade of fibrosis on day 28 (p = 0.026) and regarding epithelial metaplasia on day 5 (p = 0.052) were found between the nasal mucosa treated only with vasoconstrictors and
the nasal mucosa treated with vasoconstrictors and sea water washing. In all cases,
samples from the nasal cavities that had been washed with Physiomer appeared with
a lower grade of inflammation, fibrosis and metaplasia compared to the samples from
nasal mucosa where no nasal washing was performed.
Conclusion
Nasal irrigations with isotonic sea water, when are applied 4 h after vasoconstrictors for a long period of time, prevent nasal mucosa from histological
damage.
Keywords
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Article Info
Publication History
Accepted:
March 31,
2009
Received:
February 2,
2009
Footnotes
☆Note: Preliminary results of the present work won Awards for the 1st best Oral Presentation, entitled “A study of drug effects on the nasal mucosa” on the 22nd Congress of the European Rhinologic Society”, June 2008, Crete, Greece.
Identification
Copyright
© 2009 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
