Abstract
Objective
The aim of the present study was to investigate the proportion of sudden sensorineural
hearing loss (SSNHL) patients in a representative population cohort with migraine.
Methods
The Korean National Health Insurance Service-National Sample Cohort was collected
from 2002 to 2013. A total of 45,114 migraine participants (the migraine group) were
matched according to age, sex, income, region of residence, hypertension, diabetes,
and dyslipidemia with 180,456 controls (the control group). The migraine group included
participants diagnosed with migraine (International Classification of Disease [ICD]-10:
G43) who underwent treatment ≥2 times. The SSNHL was investigated based on the ICD-10
(H912) code and confirmed by an audiometry exam and steroid treatment. Histories of
hypertension, diabetes, dyslipidemia, ischemic heart disease, stroke, depression,
Meniere’s disease, and tinnitus were evaluated using ICD-10 codes. Crude (simple)
and adjusted hazard ratios (HRs) of SSNHL associated with migraine were analyzed using
the Cox proportional hazards model. Subgroup analyses were conducted according to
age and sex.
Results
In total, 0.9% (399/44,714) of the migraine patients and 0.6% (1,169/179,287) of the
controls were diagnosed with SSNHL (P < 0.001). The adjusted HR of migraine for SSNHL was 1.34 (95% confidence interval [CI] = 1.19–1.50, P < 0.001). Both patient age subgroups (20–59 years old and ≥60 years old) showed high adjusted HRs for SSNHL. Both the men and women presented an
elevated proportion of SSNHL cases.
Conclusion
Migraine patients had a higher likelihood of SSNHL. All age and sex migraine subgroups
showed an elevated proportion of SSNHL cases.
Keywords
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References
- Incidence of sudden sensorineural hearing loss.Otol Neurotol. 2013; 34: 1586-1589
- Sudden sensorineural hearing loss.Lancet. 2010; 375: 1203-1211
- Clinical practice Idiopathic sudden sensorineural hearing loss.N Engl J Med. 2008; 359: 833-840
- How long should the sudden hearing loss patients be followed after early steroid combination therapy?.Eur Arch Otorhinolaryngol. 2009; 266: 1391-1395
- Migraine.N Engl J Med. 2017; 377: 553-561
- Vasoactive peptide release in the extracerebral circulation of humans during migraine headache.Ann Neurol. 1990; 28: 183-187
- Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.Nat Genet. 2016; 48: 856-866
- Migraine and cardiovascular disease: a population-based study.Neurology. 2010; 74: 628-635
- Migraine is a risk factor for sudden sensorineural hearing loss: a nationwide population-based study.Cephalalgia. 2013; 33: 80-86
- Sudden sensorineural hearing loss associated with internal carotid artery pseudoaneurysm: causal or incidental.Eur Arch Otorhinolaryngol. 2013; 270: 1559-1561
- Sudden sensorineural hearing loss increases the risk of stroke: a 5-year follow-up study.Stroke. 2008; 39: 2744-2748
- Diabetes, cardiovascular risk factors and idiopathic sudden sensorineural hearing loss: a case-control study.Audiol Neurootol. 2010; 15: 111-115
- Cardiovascular and thrombophilic risk factors for idiopathic sudden sensorineural hearing loss.J Thromb Haemost. 2005; 3: 929-934
- The prevalence, impact, and treatment of migraine and severe headaches in the United States: a review of statistics from national surveillance studies.Headache. 2013; 53: 427-436
- Cohort profile: the National Health Insurance Service-National Sample Cohort (NHIS-NSC), South Korea.Int J Epidemiol. 2017; 46: e15
National Health Insurance Sharing Service. http://nhiss.nhis.or.kr/. [Accessed 2 April 2015].
- Trends in the incidence of hospitalized acute myocardial infarction and stroke in Korea, 2006–2010.J Korean Med Sci. 2013; 28: 16-24
- Stroke statistics in Korea: part I. Epidemiology and risk factors: a report from the korean stroke society and clinical research center for stroke.J Stroke. 2013; 15: 2-20
- New insights into pathophysiology of vestibular migraine.Front Neurol. 2015; 6: 12
- Trigeminal ganglion innervates the auditory brainstem.J Comp Neurol. 2000; 419: 271-285
- Trigeminal stimulation elicits a peripheral vestibular imbalance in migraine patients.Headache. 2005; 45: 325-331
- Capsaicin stimulation of the cochlea and electric stimulation of the trigeminal ganglion mediate vascular permeability in cochlear and vertebro-basilar arteries: a potential cause of inner ear dysfunction in headache.Neuroscience. 2001; 103: 189-201
- Case reports on two patients with episodic vertigo, fluctuating hearing loss and migraine responding to prophylactic drugs for migraine. Meniere’s disease or migraine-associated vertigo?.Acta Otorhinolaryngol Ital. 2010; 30: 217
- Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura.J Neurosci. 2010; 30: 8807-8814
- Episodic vertigo related to migraine (90 cases): vestibular migraine?.J Neurol. 1999; 246: 883-892
- Migraine and sudden sensorineural hearing loss.Arch Otolaryngol Head Neck Surg. 1987; 113: 325-326
- Migraine as a cause of sudden hearing loss.Headache. 1996; 36: 24-28
- Sudden sensorineural hearing loss associated with tension-type headache: a population-based study.Audiol Neurootol. 2015; 20: 122-127
- Stress and the onset of sudden hearing loss and tinnitus.Int Tinnitus J. 2000; 6: 41-49
- Does diabetes have a protective effect on migraine?.Epidemiology. 2013; 24: 129-134
- Nationwide epidemiological survey of idiopathic sudden sensorineural hearing loss in Japan.Acta Otolaryngol. 2017; 137: S8-S16
- Prevalence and impact of migraine and tension-type headache in Korea.J Clin Neurol. 2012; 8: 204-211
Article info
Publication history
Published online: October 30, 2018
Accepted:
October 17,
2018
Received:
June 26,
2018
Identification
Copyright
© 2018 Published by Elsevier B.V.