Abstract
Objective
The aim of the present study was to investigate the proportion of sudden sensorineural
hearing loss (SSNHL) patients in a representative population cohort with migraine.
Methods
The Korean National Health Insurance Service-National Sample Cohort was collected
from 2002 to 2013. A total of 45,114 migraine participants (the migraine group) were
matched according to age, sex, income, region of residence, hypertension, diabetes,
and dyslipidemia with 180,456 controls (the control group). The migraine group included
participants diagnosed with migraine (International Classification of Disease [ICD]-10:
G43) who underwent treatment ≥2 times. The SSNHL was investigated based on the ICD-10
(H912) code and confirmed by an audiometry exam and steroid treatment. Histories of
hypertension, diabetes, dyslipidemia, ischemic heart disease, stroke, depression,
Meniere’s disease, and tinnitus were evaluated using ICD-10 codes. Crude (simple)
and adjusted hazard ratios (HRs) of SSNHL associated with migraine were analyzed using
the Cox proportional hazards model. Subgroup analyses were conducted according to
age and sex.
Results
In total, 0.9% (399/44,714) of the migraine patients and 0.6% (1,169/179,287) of the
controls were diagnosed with SSNHL (P < 0.001). The adjusted HR of migraine for SSNHL was 1.34 (95% confidence interval [CI] = 1.19–1.50, P < 0.001). Both patient age subgroups (20–59 years old and ≥60 years old) showed high adjusted HRs for SSNHL. Both the men and women presented an
elevated proportion of SSNHL cases.
Conclusion
Migraine patients had a higher likelihood of SSNHL. All age and sex migraine subgroups
showed an elevated proportion of SSNHL cases.
Keywords
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Article info
Publication history
Published online: October 30, 2018
Accepted:
October 17,
2018
Received:
June 26,
2018
Identification
Copyright
© 2018 Published by Elsevier B.V.
