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Migraine increases the proportion of sudden sensorineural hearing loss: A longitudinal follow-up study

  • Author Footnotes
    1 These authors equally contributed to this study.
    So Young Kim
    Footnotes
    1 These authors equally contributed to this study.
    Affiliations
    Department of Otorhinolaryngology, Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea
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  • Author Footnotes
    1 These authors equally contributed to this study.
    Mi Kyung Kim
    Footnotes
    1 These authors equally contributed to this study.
    Affiliations
    Department of Otorhinolaryngology, Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea
    Search for articles by this author
  • Jae-Sung Lim
    Affiliations
    Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea
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  • Il Gyu Kong
    Affiliations
    Department of Otorhinolaryngology, Head & Neck Surgery, Hallym University College of Medicine, Anyang, Republic of Korea
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  • Author Footnotes
    1 These authors equally contributed to this study.
    Hyo Geun Choi
    Correspondence
    Corresponding author at: Department of Otorhinolaryngology, Head & Neck Surgery, Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro 170 beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, 14068 Republic of Korea.
    Footnotes
    1 These authors equally contributed to this study.
    Affiliations
    Department of Otorhinolaryngology, Head & Neck Surgery, Hallym University College of Medicine, Anyang, Republic of Korea
    Search for articles by this author
  • Author Footnotes
    1 These authors equally contributed to this study.
Published:October 30, 2018DOI:https://doi.org/10.1016/j.anl.2018.10.006

      Abstract

      Objective

      The aim of the present study was to investigate the proportion of sudden sensorineural hearing loss (SSNHL) patients in a representative population cohort with migraine.

      Methods

      The Korean National Health Insurance Service-National Sample Cohort was collected from 2002 to 2013. A total of 45,114 migraine participants (the migraine group) were matched according to age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia with 180,456 controls (the control group). The migraine group included participants diagnosed with migraine (International Classification of Disease [ICD]-10: G43) who underwent treatment ≥2 times. The SSNHL was investigated based on the ICD-10 (H912) code and confirmed by an audiometry exam and steroid treatment. Histories of hypertension, diabetes, dyslipidemia, ischemic heart disease, stroke, depression, Meniere’s disease, and tinnitus were evaluated using ICD-10 codes. Crude (simple) and adjusted hazard ratios (HRs) of SSNHL associated with migraine were analyzed using the Cox proportional hazards model. Subgroup analyses were conducted according to age and sex.

      Results

      In total, 0.9% (399/44,714) of the migraine patients and 0.6% (1,169/179,287) of the controls were diagnosed with SSNHL (P < 0.001). The adjusted HR of migraine for SSNHL was 1.34 (95% confidence interval [CI] = 1.19–1.50, P < 0.001). Both patient age subgroups (20–59 years old and ≥60 years old) showed high adjusted HRs for SSNHL. Both the men and women presented an elevated proportion of SSNHL cases.

      Conclusion

      Migraine patients had a higher likelihood of SSNHL. All age and sex migraine subgroups showed an elevated proportion of SSNHL cases.

      Keywords

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