Abstract
Objective
Eosinophilic otitis media (EOM) is an intractable disorder associated with bronchial
asthma and chronic rhinosinusitis with nasal polyposis. Periostin is an extracellular
matrix protein secreted by fibroblasts in response to interleukin (IL)-4 and/or IL-13
and is a known marker for eosinophilic disorders. We assessed serum periostin levels
and expression of periostin in the middle ear mucosa according to three grade of EOM
severity (grade1 to 3).
Methods
68 patients of blood and serum samples were corrected by whom diagnose bilateral EOM
in Jichi Medical University Saitama Medical Center from January 2015 to June 2017.Immunohistochemical
evaluation was performed to 18 EOM middle ears mucosa samples, which cauterized in
tree groups and compared to that of chronic otitis media (COM).
Results
Serum periostin levels was significantly higher in EOM patients than in COM patients
(EOM, 125.0 ± 45.5 ng/mL; COM, 79.4 ± 38.3 ng/mL; P<0.0001). The expression of periostin immunopositivity in the EOM middle ear mucosa
was significantly greater in severe cases (grade3 samples) than others (grade1 and
grade2 samples) (P <0.001 and P = 0.011, respectively). Periostin was expressed at the lamina propria especially
in severe EOM cases and the cases had little response to glucocorticoids treatment.
Conclusion
This study showed that periostin in the middle ear mucosa was correlated with EOM
severity, and EOM with highly expressed periostin had difficulty in glucocorticoids
treatment.
Keywords
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Article info
Publication history
Published online: June 23, 2020
Accepted:
May 27,
2020
Received:
February 14,
2020
Identification
Copyright
© 2020 Oto-Rhino-Laryngological Society of Japan Inc. Published by Elsevier B.V. All rights reserved.
