Primary cervical ganglioneuroblastoma, nodular subtype

Published:April 15, 2021DOI:


      Primary cervical ganglioneuroblastoma is rare and reports of its subtypes are limited. This case series describes two pediatric patients with the nodular subtype of primary cervical ganglioneuroblastoma with lymphatic spread. Clinical course, diagnosis, and management of this rare tumor are discussed with emphasis on the importance of including neuroblastic tumors in the differential diagnosis of pediatric neck masses. We also report the use of nerve monitoring of the recurrent laryngeal nerve as a surrogate for the vagus nerve during a pediatric neck dissection.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Auris Nasus Larynx
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Park J.R.
        • Eggert A.
        • Caron H.
        Neuroblastoma: biology, prognosis, and treatment.
        Hematol Oncol Clin North Am. 2010; 24: 65-86
        • Okamatsu C.
        • London W.B.
        • Naranjo A.
        • Hogarty M.D.
        • Gastier-Foster J.M.
        • Look A.T.
        • et al.
        Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: A report from the CCG and COG.
        Pediatr Blood Cancer. 2009; 53: 563-569
        • Lu D.
        • Liu J.
        • Chen Y.
        • Chen F.
        • Yang H.
        Primary cervical ganglioneuroblastoma: a case report.
        Medicine. 2018; (United States)
        • Al-Jassim A.H.H.
        Cervical ganglioneuroblastoma.
        J Laryngol Otol. 1987; 101: 296-301
        • Erol O.
        • Koycu A.
        • Aydin E.
        A rare tumor in the cervical sympathetic trunk: ganglioneuroblastoma.
        Case Rep Otolaryngol. 2016; 2016: 1-4
        • Keskinoz İ.
        • Erdem Ş.
        • Sert E.
        • Selcuk Ö.T.
        Cervical ganglioneuroblastoma mimicking thyroid tissue in a young adult: differential diagnosis.
        Turkiye Klin J Med Sci. 2011; 31: 1041-1045
        • Manjaly J.G.
        • Alexander V.R.C.
        • Pepper C.M.
        • Ifeacho S.N.
        • Hewitt R.J.
        • Hartley B.E.J.
        Primary cervical ganglioneuroblastoma.
        Int J Pediatr Otorhinolaryngol. 2015;
        • Moukheiber A.K.
        • Nicollas R.
        • Roman S.
        • Coze C.
        • Triglia J.M.
        Primary pediatric neuroblastic tumors of the neck.
        Int J Pediatr Otorhinolaryngol. 2001;
        • Yamamoto N.
        • Kitamura H.
        • Takagit A.S.
        • Han S.
        • Maetani T
        • Iwahashi Y.
        Cervical ganglioneuroblastoma; a case report.
        Pract Otorhinolaryngol. 1998; 91 (Basel): 1259-1263
        • Decarolis B.
        • Simon T.
        • Krug B.
        • Leuschner I.
        • Vokuhl C.
        • Kaatsch P.
        • et al.
        Treatment and outcome of ganglioneuroma and ganglioneuroblastoma intermixed.
        BMC Cancer. 2016;
        • Cohn S.L.
        • Pearson A.D.J.
        • London W.B.
        • Monclair T.
        • Ambros P.F.
        • Brodeur G.M.
        • et al.
        The International neuroblastoma risk group (INRG) classification system: an INRG task force report.
        J Clin Oncol. 2009;
        • He W.G.
        • Yan Y.
        • Tang W.
        • Cai R.
        • Ren G.
        Clinical and biological features of neuroblastic tumors: a comparison of neuroblastoma and ganglioneuroblastoma.
        Oncotarget. 2017; 8
        • Leonetti J.P.
        • Jellish W.S.
        • Warf P.
        • Hudson E.
        Intraoperative vagal nerve monitoring.
        Ear Nose Throat J. 1996;
        • Topsakal C.
        • Al-Mefty O.
        • Bulsara K.R.
        • Williford V.S.
        Intraoperative monitoring of lower cranial nerves in skull base surgery: technical report and review of 123 monitored cases.
        Neurosurg Rev. 2008; 31: 45-53