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Relationship between serum gonadal hormone levels and synkinesis in postmenopausal women and man with idiopathic facial paralysis

  • Author Footnotes
    1 These authors contributed equally to this work and should be considered co-first authors.
    Wanchun Zhu
    Footnotes
    1 These authors contributed equally to this work and should be considered co-first authors.
    Affiliations
    Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, 20092, China
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  • Author Footnotes
    1 These authors contributed equally to this work and should be considered co-first authors.
    Zheng Chen
    Footnotes
    1 These authors contributed equally to this work and should be considered co-first authors.
    Affiliations
    Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, 20092, China
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to this work and should be considered co-first authors.
    Yiman Shen
    Footnotes
    1 These authors contributed equally to this work and should be considered co-first authors.
    Affiliations
    Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, 20092, China
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  • Haopeng Wang
    Affiliations
    Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, 20092, China
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  • Xiaomin Cai
    Affiliations
    Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, 20092, China
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  • Jin Zhu
    Affiliations
    Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, 20092, China
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  • Yinda Tang
    Affiliations
    Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, 20092, China
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  • Xuhui Wang
    Correspondence
    Corresponding authors at: Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, 20092, China.
    Affiliations
    Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, 20092, China

    Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital Chongming Branch, Shanghai, 202150, China
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  • Shiting Li
    Correspondence
    Corresponding authors at: Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, 20092, China.
    Affiliations
    Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, 20092, China
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to this work and should be considered co-first authors.
Published:February 26, 2022DOI:https://doi.org/10.1016/j.anl.2022.02.005

      Abstract

      Objective

      To investigate whether serum gonadal hormone levels are correlated to the development of facial synkinesis following Bell's palsy in postmenopausal women and man.

      Methods

      A total of 149 patients with Bell's palsy were enrolled in this study. All patients were instructed in standard treatment strategy by expert staff from their first visit. The degree of synkinesis was evaluated at 12 months after the onset of facial nerve palsy based on the synkinesis scores of Sunnybrook facial grading system. The patients were divided into two groups by gender.

      Results

      Serum estradiol levels were significantly higher in patients with facial synkinesis than in patients without facial synkinesis following Bell's palsy in postmenopausal female. Male patients with facial synkinesis following Bell's palsy had a higher serum estradiol and testosterone levels. Baseline ENoG values (OR=11.144, 95% CI=1.001-124.126, p=0.008) and serum estradiol levels (OR=1.145, 95% CI=1.033-1.270, p=0.010) were the two independent predictors for facial synkinesis in postmenopausal female patients. Meanwhile, baseline ENoG values (OR=5.312, 95% CI=0.626-45.069, p=0.035), HbA1c values (OR=27.470, 95% CI=2.001-43.084, p=0.016), serum E2 levels (OR=1.298, 95% CI=1.092-1.542, p=0.003), and serum testosterone levels (OR=1.892, 95% CI=1.309-2.734, p=0.001) were the independent predictors for facial synkinesis in male patients.

      Conclusion

      Serum estradiol levels are associated with the development of facial synkinesis following Bell's palsy in postmenopausal female patients. Serum estradiol and testosterone levels are associated with the development of facial synkinesis following Bell's palsy in male patients. Serum gonadal hormone levels might be acted as potential biomarker for predicting facial synkinesis following Bell's palsy.

      Keywords

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