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Pharmacotherapy focusing on for the management of otitis media with effusion in children: Systematic review and meta-analysis

Published:March 24, 2022DOI:https://doi.org/10.1016/j.anl.2022.03.017

      Abstract

      Objective

      To examine the evidence for treating children with otitis media with effusion with pharmacotherapy.

      Data Sources

      For the systematic review, data were retrieved from PubMed, Cochrane database, and the Japan Medical Abstracts Society Database (1st January 1995 through 31th May 2019).

      Study Selection

      Articles addressing pharmacotherapy for the management of otitis media with effusion in children were selected in English.

      Data Extraction

      The database was searched using the keywords “Otitis Media with effusion or secretory otitis media” and the following medical agents: carbocysteine, antihistamines, leukotriene receptor antagonist, and steroid nasal spray.

      Data Synthesis

      After a critical review of 18 studies, studies addressing steroid nasal spray were eligible for quantitative synthesis. Intranasal steroids for OME showed no benefit with OR 1.155 (95% CI 0.834-1.598) within one month. Conversely, intranasal steroids have effects for OME with OR 1.858 (95% CI 1.240-2.786) for more than one month.

      Conclusions

      We found evidence of benefit from treatment of OME in children with intranasal steroids and S-carboxymethylcysteine at longer-term follow-up.

      Keywords

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