Abstract
Objective
To analyze the incidence of pharyngeal reflux in laryngopharyngeal reflux patients
over a 24-hour period and find out the key timing of pharyngeal reflux.
Methods
We reviewed 69 patients who visited our clinic with LPR-related symptoms and were
proven to have pharyngeal reflux via 24‐hour multichannel intraluminal impedance‐pH
(24hr MII‐pH) monitoring. Quantitative analysis was conducted for the LPR profiles,
such as the acidity of reflux, nighttime reflux, and positional reflux. The time series
of pharyngeal reflux episodes and mealtimes were analyzed over a 24-hour period. Also,
we recruited 26 normal controls. We compared the timing of pharyngeal reflux between
LPR patients and asymptomatic controls.
Results
The quantitative analysis revealed that pharyngeal reflux occurred 4.88 ± 4.59 times
over 24 hours. Weakly acidic pharyngeal reflux was more abundant than acidic or weakly
alkaline reflux. Pharyngeal reflux occurred mainly during daytime in the upright position.
The most frequent timing of pharyngeal reflux episodes was within 2 hours after meals.
Additionally, there was no significant difference of the timing of post-prandial reflux
between LPR patients and asymptomatic controls.
Conclusion
The key timing of pharyngeal reflux in patients with LPR was post-prandial 2 hours.
Keywords
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Article info
Publication history
Published online: December 03, 2022
Accepted:
November 17,
2022
Received:
October 10,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc. Published by Elsevier B.V. All rights reserved.
