Abstract
Pollen-food allergy syndrome (PFAS) is an immunoglobulin E (IgE)-mediated allergic
reaction caused when patients with pollen allergy ingest food having cross-reactivity
with pollen. To date, no effective treatment method for this has been established.
Here we report the case of a patient with PFAS who experienced lip edema, causing
difficulties in treatment. This report describes the case of a 12-year-old boy with
perennial allergic rhinitis since the age of 8 years. After ingesting fresh fruits
and raw vegetables at the age of 11 years, he started to experience lip edema repeatedly.
Thus, the patient was referred to our department. Based on the results of serum antigen-specific
IgE, prick-to-prick, and allergen component tests, he was diagnosed with PFAS.
He has been instructed to avoid causative food. Furthermore, the treatment using an
antihistamine and antileukotriene receptor antagonist was initiated for pollen allergy.
Sublingual immunotherapy (SLIT) for Japanese cedar pollen was initiated because the
patient experienced severe nasal allergy symptoms during the dispersal season of this
pollen. These treatments alleviated the nasal symptoms; however, the lip edema persisted.
Omalizumab administration improved the lip edema. The combination of SLIT and omalizumab
may be an effective treatment option for patients with PFAS.
Key words
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Article info
Publication history
Published online: December 27, 2022
Accepted:
December 2,
2022
Received:
June 18,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc. Published by Elsevier B.V. All rights reserved.
