Abstract
Objective
The prognostic role of pretreatment C-reactive protein (CRP) has been reported for
head and neck cancer. However, little is known about the relationship between the
changes in CRP levels during treatment and prognosis. This study aimed to investigate
the correlation between CRP elevation during concurrent chemoradiotherapy (CCRT) and
survival outcomes.
Methods
The medical records of patients with oropharyngeal, hypopharyngeal, and laryngeal
cancer treated with CCRT at the University of Tsukuba Hospital and National Hospital
Organization Mito Medical Center from April 2014 to December 2019 were retrospectively
reviewed. Patients were divided into normal (<0.3 mg/dl) and elevated (≥0.3 mg/dl)
CRP groups according to the CRP level after the first cycle of cisplatin. The primary
endpoint was progression-free survival (PFS).
Results
A total of 74 patients were enrolled, of whom 36 (49%) showed elevated CRP levels
after the first cycle of cisplatin. The 3-year PFS was 83.3% and 61.0% in the normal
and elevated CRP groups, respectively, showing significant differences between the
two groups.
Conclusion
Elevated CRP levels after the first cycle of cisplatin is an objective predictive
marker for survival in patient with head and neck squamous cell carcinoma treated
with CCRT.
Keywords
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Article info
Publication history
Published online: January 03, 2023
Accepted:
December 26,
2022
Received:
August 23,
2022
Publication stage
In Press Corrected ProofFootnotes
Prior presentation: None
Identification
Copyright
© 2023 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc. Published by Elsevier B.V.
