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Complement level and tuberculin reactivity were measured as possible indices of the
humoral and cell-mediated immune status of 167 patients with head and neck cancer
examined at the Department of Otorhinolaryngology, Keio University School of Medicine,
Tokyo, between July 1974 and June 1979. Complement level (CH50) was measured according to Mayer's method. In tuberculin tests, 0.1 ml of purified
protein-derivative solution (0.5 μg/ml) was injected intracutaneously and formation
of erythema and induration was measured 48 hr later. Results were analyzed according
to the method of Nishioka, in which the following six stages were classified: stage
0, unaltered tuberculin reactivity and depressed complement level; stage I, unaltered
tuberculin reactivity and normal complement level; stage II, unaltered tuberculin
reactivity and elevated complement level; stage III, depressed tuberculin reactivity
and elevated complement level; stage IV, depressed tuberculin reactivity and normal
complement level; stage V, depressed tuberculin reactivity and depressed complement
level.
Patients were divided into seven different groups: pre-treatment, postradiotherapy,
post-surgery, remission, 5-year survival, recurrence and metastasis, and terminal.
Complement level was elevated in tumorbearing hosts, meanwhile it was within the normal
range in non-tumor bearing hosts. Values of tuberculin reactivity and CH50 were averaged within each group and analyzed as described above. The results of this
study demonstrate that the complement system is elevated while the cell-mediated immune
system is depressed in patients with malignant tumors. Thus, this classification system
may prove clinically useful in planning treatment of cancer patients and in estimating
their prognosis.
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References
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Article info
Publication history
Received:
April 1,
1981
Identification
Copyright
© 1981 Society for Promotion of International Otorhinolaryngology (SPIO). Published by Elsevier Inc. All rights reserved.
