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A Study of Experimental Sinusitis in Rabbits

  • Takuo Maeyama
    Correspondence
    Request reprint from: Dr. T. Maeyama, Department of Otolaryngology, Faculty of Medicine, Kagoshima University, 1208-1 Usuki-cho, Kagoshima 890, Japan
    Affiliations
    Department of Otolaryngology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
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      Sinusitis was experimentally induced in rabbits by injecting one ml of casitone semi-liquid agar containing Staphylococcus aureus 209P in the order of 107 per ml into rabbit's bilateral paranasal sinuses (which had been sensitized with a 2.5 % concentration of a purified egg white albumin solution) through a percutaneous route with a sterilized syringe. Two weeks after the last injection the rabbits were sacrificed and dissected. Light microscopic (LM) and scanning electron microscopic (SEM) examination of pathomorphological changes in this experimental model revealed that chronic inflammation developed in the mucous membranes of the paranasal sinuses at a high incidence.
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      References

        • Albegger K.W.
        Abnormal “hair-like“ filaments in chronic maxillary sinusitis.
        A scanning electron microscopic investigation. Arch. Oto-rhino-laryng. 1978; 220: 239-249
        • Aust R.
        • Drettner B.
        Oxygen tension in the human maxillary sinus under normal and pathological conditions.
        Acta Otolaryng. 1974; 78: 264-269
        • Aust R.
        • Drettner B.
        The functional size of the human maxillary ostium in vivo.
        Acta Otolaryng. 1974; 78: 432-435
        • Baba S.
        Clinical and experimental studies on anaerobes in chronic sinusitis.
        J. Nagoya City Univ. Med. Ass. 1970; 20: 800-852
        • Carenfelt C.
        • Lundberg C.
        Purulent and non-purulent maxillary sinus secretions with respect to pO2, pCO2 and pH.
        Acta Otolaryng. 1977; 84: 138-144
        • Carenfelt C.
        • Lundberg C.
        The role of local gas composition in pathogenesis of maxillary sinus empyema.
        Acta Otolaryng. 1978; 85: 116-121
        • Drettner B.
        The permeability of the maxillary ostium.
        Acta Otolaryng. 1965; 60: 304-314
        • Drettner B.
        Measurement of the resistance of the maxillary ostium.
        Acta Otolaryng. 1965; 60: 499-505
        • Maeyama T.
        • et al.
        Cystic lesion of paranasal sinuses-clinicopathological and scanning elec tron microscopic observation.
        Jibi Inkoka (Otolaryngology Tokyo). 1981; 53: 103-108
        • Maeyama T.
        • et al.
        Experimental sinusitis in rabbits—with special attention to surface ultra structure—.
        Rhinology. 1981; (in press)
        • Mygind N.
        • Bretlau P.
        Scanning electron microscopic studies of the human nasal mucosa in normal persons and in patients with perennial rhinitis. I. Cilia and microvilli.
        Acta allerg. 1973; 28: 9-27
        • Mygind N.
        • Bretlau P.
        Scanning electron microscopic studies of the human nasal mucosa in normal persons and in patients with perennial rhinitis. II. Secretion.
        Acta allerg. 1974; 29: 261-280
        • Mygind N.
        Scanning electron microscopy of the human nasal mucosa.
        Rhinology. 1975; 13: 5775
        • Nakamura M.
        The morphological and histochemical studies of experimental sinusitis with reference to the epithelium of the mucous membrane.
        Pract. Otol. Kyoto. 1967; 60: 641-652
        • Ohyama M.
        • et al.
        Scanning electron microscopic observations of the mucous membrane of the human chronic sinusitis.
        J. Jpn. Rhinol. Soc. 1971; 14: 16-17
        • Ohyama M.
        • et al.
        The efficacy of seaprose on experimental sinusitis-with special reference to the light and scanning electron microscopic observations-.
        Pract. Otol. Kyoto. 1981; 74: 487-498
        • Okuda M.
        • Kanda T.
        Scanning electron microscopy of the nasal mucous membrane.
        Acta Otolaryng. 1973; 76: 283-294
        • Reimer Å.
        • Toremalm N.G.
        The mucociliary activity of the upper respiratory tract. II. A method for in vivo studies on maxillary sinus mucosa of animals and human beings.
        Acta Otolaryng. 1978; 86: 283-288
        • Sakakura Y.
        A study of ciliary activity in culture of adult human nasal mucosa.
        Mie Med. J. 1966; 15: 211-229
        • Takasaka T.
        • et al.
        Atypical cilia of the human nasal mucosa.
        Ann. Otol. Rhinol. Laryngol. 1980; 89: 37-45